Stephy Publishers

Journal of Cardiology and Current Trends in Surgery

Evaluation of Arterial Hypertension Care in Four Brazilian Metropoles

Hypertension (AH) is one of the most prevalent chronic diseases in Brazil, which, in 2018, affected about 24.5% of the adult population, reaching 59.3% of people aged 65 and over. (Ministry of Health 2020)  These levels of prevalence and with an increasing trend have a major impact on morbidity and mortality, with high social cost. In this context, the Unified Health System (SUS) has been developing a strategic action plan based on conceptual bases that involve a comprehensive approach to chronic non-communicable diseases, especially AH, at all levels of activity (promotion, prevention and comprehensive care and Organization health services for the care of patients with chronic diseases). The guidelines of the Strategic Action Plan recommend that the care offered should use, in addition to pharmacological Therapy, educational actions to change lifestyle (encouraging the practice of physical activity, the consumption of healthy foods and the reduction of salt consumption),  monitoring the disease by means of routine examinations and searching for damage to a target organ (ECG and Echo cardiogram) in specific populations.

https://www.stephypublishers.com/cardiology-and-current-trends-in-surgery/pdf/JCCTS.MS.ID.000502.pdf

Stephy Publishers

Journal of Cardiology and Current Trends in Surgery

The Diabetic Foot: New Challenges in Management and Care

Early diagnosis of diabetic polyneuropathy (DPN) is important for several reasons. First, careful and regular medical follow-up should be offered to avoid neuropathic DFUs. Secondly, optimised glycaemic control and correction of other vascular risk factors (e.g. hypertension, dyslipidaemia etc) should be diligently pursued. Finally, daily foot hygiene and appropriate footwear are indispensable. A number of practical bedside clinical tools contribute to improved early diagnosis, such as the indicator test Neuropad assessing sweat production in the feet, Vibra Tip, the portable NC-stat DPN Check device and others. Neuropad has been extensively studied and confirmed as an excellent, highly reproducible and practical screening tool with very high sensitivity and negative predictive value for DPN, which renders itself even for patient self-examination. Vibra Tip is a pocket-sized portable device which measures vibration perception at the hallux, whose diagnostic utility has recently been confirmed. NC-stat DPN Check is a special device for automated nerve conduction study of the sural nerve, which may be used by all health care professional after minimal training. We have shown that it yields very high diagnostic performance (sensitivity, specificity, positive and negative predictive value) in both diabetes types.

https://www.stephypublishers.com/cardiology-and-current-trends-in-surgery/pdf/JCCTS.MS.ID.000501.pdf 

 

 Stephy Publishers

International Journal of Pharmaceutical Sciences - (IJPS)

Title: Formulation, Development and Evaluation of Fast Disintegrating Piroxicam Tablets

Piroxicam is a non-steroidal anti-inflammatory drug used in the treatment of osteo arthritis, rheumatoid arthritis, ankylosing spondylitis, classified in the Bio pharmaceutics Drug Classification system as a Class II drug because it has low solubility and high permeability. It demonstrates a slow and gradual absorption via the oral route and has a long half-life of elimination, rendering a prolonged therapeutic action and a delayed onset of anti-inflammatory and analgesic effect. Thus an attempt is made to formulate piroxicam fast disintegrating tablet so that it helps to render faster onset of anti inflammatory and analgesic effect. To increase the solubility of piroxicam solid dispersion method is opted in the present investigation. Study proposes the use of PVPk30 to prepare solid dispersion of piroxicam and comparison of its invitro dissolution with pure piroxicam. Fast Dissolving tablets can be prepared by conventional direct compression method using solid dispersion. For better Hardness, less friability, faster wetting time and less moisture uptake combination of both MCC and Mannitol are used in the formulation.

 

https://www.stephypublishers.com/international-journal-of-pharmaceutical-sciences/pdf/IJPS.MS.ID.000501.pdf